Recent advances on smart TiO₂ nanotube platforms for sustainable drug delivery applications.

IF 3.1 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Research in Chinese Universities Pub Date : 2016-12-20 eCollection Date: 2017-01-01 DOI:10.2147/IJN.S117498

Qun Wang, Jian-Ying Huang, Hua-Qiong Li, Allan Zi-Jian Zhao, Yi Wang, Ke-Qin Zhang, Hong-Tao Sun, Yue-Kun Lai

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Abstract

To address the limitations of traditional drug delivery, TiO₂ nanotubes (TNTs) are recognized as a promising material for localized drug delivery systems. With regard to the excellent biocompatibility and physicochemical properties, TNTs prepared by a facile electrochemical anodizing process have been used to fabricate new drug-releasing implants for localized drug delivery. This review discusses the development of TNTs applied in localized drug delivery systems, focusing on several approaches to control drug release, including the regulation of the dimensions of TNTs, modification of internal chemical characteristics, adjusting pore openings by biopolymer coatings, and employing polymeric micelles as drug nanocarriers. Furthermore, rational strategies on external conditions-triggered stimuli-responsive drug release for localized drug delivery systems are highlighted. Finally, the review concludes with the recent advances on TNTs for controlled drug delivery and corresponding prospects in the future.

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用于可持续给药应用的智能 TiO2 纳米管平台的最新进展。

为了解决传统给药方式的局限性，二氧化钛纳米管（TNTs）被认为是一种很有前途的局部给药系统材料。由于TNTs具有良好的生物相容性和物理化学特性，通过简便的电化学阳极氧化工艺制备的TNTs已被用于制造新的药物释放植入物，以实现局部给药。本综述讨论了应用于局部给药系统的 TNTs 的发展情况，重点介绍了几种控制药物释放的方法，包括调节 TNTs 的尺寸、改变其内部化学特性、通过生物聚合物涂层调整孔隙大小以及采用聚合物胶束作为药物纳米载体。此外，还重点介绍了用于局部给药系统的外部条件触发式刺激响应药物释放的合理策略。最后，本综述总结了 TNTs 在可控药物递送方面的最新进展以及相应的未来前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Research in Chinese Universities 化学-化学综合

CiteScore

5.30

自引率

6.50%

发文量

152

审稿时长

3.0 months

期刊介绍： The journal publishes research articles, letters/communications and reviews written by faculty members, researchers and postgraduates in universities, colleges and research institutes all over China and overseas. It reports the latest and most creative results of important fundamental research in all aspects of chemistry and of developments with significant consequences across subdisciplines. Main research areas include (but are not limited to): Organic chemistry (synthesis, characterization, and application); Inorganic chemistry (bio-inorganic chemistry, inorganic material chemistry); Analytical chemistry (especially chemometrics and the application of instrumental analysis and spectroscopy); Physical chemistry (mechanisms, catalysis, thermodynamics and dynamics); Polymer chemistry and polymer physics (mechanisms, material, catalysis, thermodynamics and dynamics); Quantum chemistry (quantum mechanical theory, quantum partition function, quantum statistical mechanics); Biochemistry; Biochemical engineering; Medicinal chemistry; Nanoscience (nanochemistry, nanomaterials).