Characterization of Molecularly Imprinted Polymers (MIPs) as Cholesterol-Absorbing Materials

Indonesian Journal of Chemical Science and Technology (IJCST) Pub Date : 2023-07-31 DOI:10.24114/ijcst.v6i2.49367

Nadia Nadia, D. Kurniawati, Alizar Alizar

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Abstract

Molecularly Imprinted Polymer (MIP) membranes as cholesterol absorbers have been successfully synthesized. MIP membranes can absorb cholesterol molecules because they have cavite (pores) and active groups that are selective and sensitive to cholesterol molecules. MIP membranes are synthesized from butyl acrylate monomers, cross-linkers, ethylene glycol dimethacrilate (EGDMA), initiators of 2- 2-dimethoxy-2-phenylacetophenone (DMPP, sodium dodecyl sulfate (SDS) as surfactants, and cholesterol as templates. MIP membranes are synthesized using photopolymerization irradiated with UV light. The results obtained in the form of powder solids can be characterized using UV-Vis spectrophotometry. The results obtained by UV-Vis spectrophotometry showed that the MIP membrane prepared a standard curve with a linear regression equation y = 0.0054x-0.007 with a value of R2 = 0.9982. This suggests that MIP membranes are selective and sensitive to analytes. At optimum absorption of the MIP-cholesterol membrane can absorb cholesterol molecules in the amount of 0.020 grams of cholesterol composition within 20 minutes

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分子印迹聚合物(MIPs)作为胆固醇吸收材料的表征

分子印迹聚合物(MIP)膜作为胆固醇吸收剂已被成功地合成。MIP膜可以吸收胆固醇分子，因为它们具有空腔(孔)和活性基团，对胆固醇分子具有选择性和敏感性。MIP膜是由丙烯酸丁酯单体、交联剂、乙二醇二甲丙烯酸酯(EGDMA)、2- 2-二甲氧基-2-苯基苯乙酮(DMPP)引发剂、十二烷基硫酸钠(SDS)作为表面活性剂和胆固醇作为模板合成的。采用紫外光聚合法制备了MIP膜。以粉末固体形式得到的结果可以用紫外可见分光光度法进行表征。紫外可见分光光度法测定结果表明，MIP膜制备的标准曲线线性回归方程为y = 0.0054x-0.007, R2 = 0.9982。这表明MIP膜对分析物具有选择性和敏感性。在最佳吸收条件下，mip -胆固醇膜可在20分钟内吸收量为0.020克的胆固醇分子组成

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Indonesian Journal of Chemical Science and Technology (IJCST)

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