Synthesis of some new diarylmethanes by McMurry coupling reaction: characterization and antibacterial activity

Ameni Hadj Mohamed, Meral Görmen, M. E. Arbi, Moncef Msaddek, M. S. Veitía
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引用次数: 1

Abstract

Diarylmethanes (DAMs) and triarylmethanes (TAMs), molecules bearing two or three aryl groups (phenyls or heterocycles) bonded to a central carbon atom, have numerous applications. The biological and therapeutic relevancy of this class of molecules has been demonstrated for various applications in the field of antimicrobials, infectious, cardiovascular and nervous system disorders, genital tract diseases, estrogen-related disorders and bone remodeling. These interesting compounds have also been used as starting materials for the development of high value-added molecules. We report here the synthesis of two new diarylmethanes using a McMurry coupling reaction as well as their antibacterial evaluation.
McMurry偶联反应合成新二芳基甲烷:表征及抑菌活性
二芳基甲烷(dam)和三芳基甲烷(tam)是由两个或三个芳基(苯基或杂环)与中心碳原子结合而成的分子,具有广泛的应用。这类分子的生物学和治疗相关性已被证明在抗菌剂、传染病、心血管和神经系统疾病、生殖道疾病、雌激素相关疾病和骨重塑领域的各种应用。这些有趣的化合物也被用作开发高附加值分子的起始材料。本文报道了用McMurry偶联反应合成两种新的二芳基甲烷及其抗菌性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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