Synthesis of some new diarylmethanes by McMurry coupling reaction: characterization and antibacterial activity

Abstract

Diarylmethanes (DAMs) and triarylmethanes (TAMs), molecules bearing two or three aryl groups (phenyls or heterocycles) bonded to a central carbon atom, have numerous applications. The biological and therapeutic relevancy of this class of molecules has been demonstrated for various applications in the field of antimicrobials, infectious, cardiovascular and nervous system disorders, genital tract diseases, estrogen-related disorders and bone remodeling. These interesting compounds have also been used as starting materials for the development of high value-added molecules. We report here the synthesis of two new diarylmethanes using a McMurry coupling reaction as well as their antibacterial evaluation.