An Observational Prospective Study on Prevalence and Monitoring of Adverse Drug Reactions in Tertiary Care Teaching Hospital

Abstract

Objective: To study the prevalence of ADRs in the in-patient departments of General Medicine, Pediatrics, Dermatology at tertiary care hospital. Materials and Methods: An Observational Prospective Study was designed from February to July 2015 in which Prevalence of ADR was calculated. A total of 107 ADR’s were observed from 1334 patients. ADR’s were evaluated for causality by WHO-UMC Scale, Naranjo’s scale, Severity by Hartwig & Siegel scale, Preventability by Schumock & Thornton and classification by Rawling & Thompson criteria. Results: Prevalence of ADR’s was found to be 8.02% and male to female ratio was 0.81. ADR’s mostly occurred in the age group 31-40 (27.10%). Skin was found to be the most commonly affected organ system (24.29%) among which rashes and urticaria were the most common type of ADR’S reported, majority of the adverse drug reactions were due to Antimicrobials (22.42%). For Casuality of ADR’s according to Naranjo Scale 26.16% of adverse drug reactions were assessed Original Research Article Gangisetty et al.; BJPR, 11(2): 1-9, 2016; Article no.BJPR.24288 2 to be probable, using WHO-UMC scale 33.64% were considered as probable. Similarly Severity assessment shows majority of the reactions as moderate (53.27%). Conclusion: By early detection of adverse drug reactions, necessary action can be taken to prevent mortality & morbidity from such reactions.