Association of Ki-67 Level on Bone Destruction in Chronic Suppurative Otitis Media Patients with Cholesteatoma

Lina Lasminingrum, Sally Mahdiani, Dina Riana
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引用次数: 2

Abstract

Background: Chronic suppurative otitis media (CSOM) with cholesteatoma is one of the most common chronic infections found in developing countries. Cholesteatoma will stimulate bone resorption from the epithelial and stromal cells resulting in cytokine and keratinocyte formation, as well as mastoid bone destruction. The Ki-67 found in the proliferating cell shows that this protein plays an important role as a cell division process marker. Objective: Analyzing the association of Ki-67 on bone destruction in CSOM with cholesteatoma. Method: Participants in this study were CSOM patients with cholesteatoma who underwent surgery. Participants were assessed for bone destruction based on CT scan examination and confirmed during surgery. Examination of Ki-67 levels was carried out by taking cholesteatoma tissue at the time of surgery and analyzed using the ELISA method. The results of the examination were analyzed using the Spearman's rank correlation, Pearson’s correlation and logistic regression with p < 0.05. Results: The value of Ki-67 levels at each degree of destruction was degree 1 of 0.301, degree 2 of 0.36 ± 0.34, degree 3 of 0.41 ± 0.07, degree 4 of 0.60 ± 0.85, degree 5 of 0.74 ± 0.12, and degree 6 equal to 0.90 (r = 0.906; p = 0.001). In addition, there was a significant relationship between symptoms duration on bone destruction (r = 0.913; p = 0.001) and levels of Ki-67 (r = 0.887; p < 0.001). The regression coefficient was 0.079 for the independent variable, bone destruction with p = 0.009, and the regression coefficient 0.024 for symptoms duration with p = 0.014. Conclusion: Increased Ki-67 level in cholesteatoma is associated with bone destruction degree in CSOM patients with cholesteatoma.
Ki-67水平与慢性化脓性中耳炎合并胆脂瘤患者骨破坏的关系
背景:慢性化脓性中耳炎合并胆脂瘤是发展中国家最常见的慢性感染之一。胆脂瘤会刺激上皮细胞和基质细胞的骨吸收,导致细胞因子和角质细胞的形成,以及乳突骨的破坏。在增殖细胞中发现的Ki-67表明该蛋白作为细胞分裂过程的标志物起着重要的作用。目的:分析Ki-67与CSOM骨破坏与胆脂瘤的关系。方法:本研究的参与者是接受手术治疗的CSOM胆脂瘤患者。参与者在CT扫描检查的基础上评估骨破坏,并在手术中确认。手术时取胆脂瘤组织检测Ki-67水平,ELISA法分析。检验结果采用Spearman秩相关、Pearson相关和logistic回归分析,p < 0.05。结果:各破坏程度Ki-67值分别为1级0.301、2级0.36±0.34、3级0.41±0.07、4级0.60±0.85、5级0.74±0.12、6级0.90 (r = 0.906;P = 0.001)。此外,症状持续时间与骨破坏之间存在显著相关(r = 0.913;p = 0.001)和Ki-67水平(r = 0.887;P < 0.001)。自变量骨破坏的回归系数为0.079,p = 0.009;症状持续时间的回归系数为0.024,p = 0.014。结论:CSOM合并胆脂瘤患者胆脂瘤组织中Ki-67水平升高与骨破坏程度相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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