A Review on Cancer Stem Cells in Vasculogenic Mimicry Formation: A New Dimension for Targeted Therapy

IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Advanced Oral Research Pub Date : 2020-11-06 DOI:10.1177/2320206820960862

A. Murugesan, B. Sekar, R. Saranyan, E. Manivannan, M. Rajmohan

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引用次数: 1

Abstract

Aim: Cancer stem cells (CSCs) or tumor-initiating cells have self-renewal and uncontrolled tumor growth capacity that promotes metastasis and recurrence. Challenges in anticancer have found a lateral dimension of treatment against a new pattern of tumor microcirculation, known as vasculogenic mimicry (VM), involved in cancer progression. Increasing evidence suggest that CSCs are involved in the formation of VM. In this review the correlation between CSCs and VM formation is been enlightened. Materials and Methods: The literature search was done in Medline, PubMed, Wiley, Science Direct, and Scopus. The keywords used for database search were cancer stem cells, vasculogenic mimicry, and anticancer therapy. Results: A total of 112 articles appeared from various sources, of which 102 were subjected for screening and 20 were related to the research objective. Conclusion: Based on the literature a positive correlation exists between CSC and VM, which plays a key role in tumor progression, and hence, can serve as a potential target in anticancer therapy.

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肿瘤干细胞在血管模拟形成中的研究进展:靶向治疗的新方向

目的:肿瘤干细胞或肿瘤启动细胞具有自我更新和不受控制的肿瘤生长能力，促进肿瘤转移和复发。抗癌方面的挑战已经发现了一种针对肿瘤微循环新模式的横向治疗，即参与癌症进展的血管生成模拟(VM)。越来越多的证据表明csc参与了VM的形成。本文综述了CSCs与VM形成的关系。材料和方法:文献检索在Medline, PubMed, Wiley, Science Direct和Scopus中完成。用于数据库搜索的关键词是癌症干细胞、血管生成模拟和抗癌治疗。结果:各种来源共收录文献112篇，其中筛选102篇，与研究目的相关的文献20篇。结论:文献显示CSC与VM呈正相关，在肿瘤进展中起关键作用，可作为抗癌治疗的潜在靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Advanced Oral Research DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

1.10

自引率

0.00%

发文量