Unusual Human Papillomavirus–Related Neoplasms of the Head and Neck: A Case Series and Review of Literature

IF 0.2
Kyle M. Devins, Z. Baloch, V. Livolsi
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引用次数: 0

Abstract

Oropharyngeal squamous cell carcinoma accounts for the majority of human papillomavirus (HPV)–related neoplasms in the head and neck. However, recent studies have identified high-risk HPV in other, clinicopathologically distinct tumors in this region. We report a series of cases involving two unique HPV-mediated neoplasms. Human papillomavirus–related multiphenotypic sinonasal carcinoma is a locally aggressive tumor arising exclusively in the sinonasal tract with pathologic features reminiscent of high-grade adenoid cystic carcinoma. Ciliated adenosquamous carcinoma often presents as a unilateral neck mass and consists of admixed nonkeratinizing squamous cell carcinoma and glandular elements, which may be deceptively bland. Cilia are often present, which are traditionally associated with benignity and may lead to misdiagnosis as a benign branchial cleft cyst. In most cases, an oropharyngeal primary tumor is later identified. Despite aggressive features, both entities have a relatively favorable prognosis. These unusual tumors present unique diagnostic challenges that require particular attention to prevent misdiagnosis and mistreatment.
头颈部罕见的人类乳头瘤病毒相关肿瘤:病例系列和文献综述
口咽鳞状细胞癌占头颈部人类乳头状瘤病毒(HPV)相关肿瘤的大多数。然而,最近的研究已经在该地区的其他临床病理不同的肿瘤中发现了高危HPV。我们报告了一系列涉及两种独特的hpv介导肿瘤的病例。人乳头瘤病毒相关的多表型鼻窦癌是一种仅发生在鼻窦炎的局部侵袭性肿瘤,其病理特征与高级别腺样囊性癌相似。纤毛腺鳞状癌通常表现为单侧颈部肿块,由非角化鳞状细胞癌和腺体成分混合组成,可能看起来平淡无奇。纤毛通常存在,传统上与良性相关,并可能导致误诊为良性鳃裂囊肿。在大多数病例中,口咽原发肿瘤后来才被发现。尽管具有侵袭性特征,但两种实体的预后相对较好。这些不寻常的肿瘤提出了独特的诊断挑战,需要特别注意,以防止误诊和误治。
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期刊介绍: Each issue of Pathology Case Reviews examines one vital theme in the field with peer-reviewed, clinically oriented case reports that focus on diagnosis, specimen handling and reports generation. Each theme-oriented issue covers both histopathologic and cytopathologic cases, offering a comprehensive perspective that includes editorials and review articles of the newest developments in the field, differential diagnosis hints, applications of new technologies, reviews of current issues and techniques and an emphasis on new approaches.
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