Hepatoprotective activity of Marrubium vulgare against paracetamol induced toxicity

Abstract

Aim

The present work was carried out to evaluate the hepatoprotective activity of Marrubium vulgare against paracetamol toxicity in Wistar rats.

Methods

Hepatoprotective properties of the methanol extract of whole plant were evaluated on paracetamol induced hepatotoxicity. Hepatotoxicity was induced in albino Wistar rats by the administration of paracetamol (2 g/kg), p.o. for 7 days. Methanol extract of Marrubium vulgare was administered at the doses 100 and 200 mg/kg/day, p.o. for 7 days. Serum analysis was performed to estimate the levels of ALT, AST, ALP, albumin, total bilirubin, and triglycerides. The liver was solated and homogenized for the estimation of glutathione and malondialdehyde. Histopathology studies were also performed on the catalase liver samples.

Results

The toxic effects of paracetamol were significantly controlled in the extract treated groups which was manifested by the restoration of serum biochemical parameters to near normal levels.

Conclusions

From the study it was concluded that M. vulgare possess significant hepatoprotective properties.