Thiophene Donor for NIR-II Fluorescence Imaging Guided Photothermal/Photodynamic/Chemo Combination Therapy

Qiang Liu, Jiangwei Tian, Ye Tian, Qinchao Sun, Dan Sun, Feifei Wang, Haijun Xu, G. Ying, Wang Jigang, A. Yetisen, Nan Jiang
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Abstract

Organic fluorophores/photosensitizers have been widely used in biological imaging and photodynamic and photothermal combination therapy in the first near-infrared windows. However, their applications in the second near-infrared (NIR-II) windows are still limited primarily owing to low fluorescence quantum yields (QYs). Here, a boron dipyrromethene (BDP) as the molecularly engineered thiophene donor unit with high QYs to the redshift is created. Thiophene insertion initiates substantial redshifts of the absorbance, as compared to its counterparts that introduce iodine. The fluorescent molecule can be triggered by a NIR laser with a single wavelength, producing emission in the NIR-II windows. Single NIR laser triggered phototherapeutic nanoparticles (NPs) are developed by encapsulating the BDP and chemotherapy drug docetaxel (DTX) using a synthetical amphiphilic poly(styrene- co -chloromethyl styrene)-graft-poly(ethylene glycol) functionalized with folic acid (FA). These BDP-T-N-DTX-FA NPs not only show superior solubility and high singlet oxygen quantum yield (ΦΔ =62%), but also demonstrate a single NIR laser-triggered multifunctional characteristics. After intravenous injection of the NPs into 4T1 tumor-bearing mice, the accumulation of the NPs in the tumor presented a high signal-to-background ratio (11.8). Furthermore, the 4T1 tumors in mice were almost eradicated by released DTX and PDT/PTT combination therapy from the BDP-T-N-DTX-FA NPs under the single NIR laser excitation.
用于NIR-II荧光成像引导光热/光动力/化学联合治疗的噻吩供体
有机荧光团/光敏剂已广泛应用于生物成像和光动力光热联合治疗的第一个近红外窗口。然而,它们在第二近红外(NIR-II)窗口中的应用仍然受到限制,主要是由于低荧光量子产率(QYs)。在这里,一个硼二吡咯甲烷(BDP)作为分子工程噻吩供体单位具有高的红移QYs。与引入碘相比,噻吩的插入引发了吸光度的实质性红移。荧光分子可以由具有单一波长的近红外激光器触发,在NIR- ii窗口中产生发射。采用叶酸(FA)功能化的两亲性聚(苯乙烯- co -氯甲基苯乙烯)接枝聚乙二醇包封BDP和化疗药物多西他赛(DTX),制备了单次近红外激光触发光疗纳米颗粒(NPs)。这些BDP-T-N-DTX-FA NPs不仅具有优异的溶解度和高单线态氧量子产率(ΦΔ =62%),而且具有单次近红外激光触发的多功能特性。向4T1荷瘤小鼠静脉注射NPs后,NPs在肿瘤中的积累呈现高信本比(11.8)。此外,在单次近红外激光激发下,BDP-T-N-DTX-FA NPs释放DTX和PDT/PTT联合治疗小鼠4T1肿瘤几乎被根除。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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