Synthesis of New Azo–Schiff Base Complexes and Study of their Antibacterial Activity

Abstract

In this research, we synthesized new azo-schiff base derivatives (4-9). These derivatives of azo compounds (1-3) that synthesized from 4-ethoxyaniline and drivatives of aldehyde such as, 4-aminobenzaldehyde, 4- hydroxybenzaldehyde and 4-ethoxybenzaldehyse to produce azo compounds (1-3). The compounds (1-3) reacted with differents aldehyde such as, isonicotinic hydrazide to produce N'-[(Z)-{3-[(E)-(4-ethoxyphenyl)diazenyl]-4-subs.phenyl}-methylidene]pyridine-4-carbohydrazide derivatives (4-6) and 3-amino pyridine to produce 2-[(E)-(4-ethoxyphenyl)diazenyl]-4-{(E)-[(pyridin-3-yl)imino]-methyl}subsbenzene derivatives (7-9). These compounds were characterization by spectroscopy methods such as, FTIR and 1HNMR. Some compounds (4, 6 and 9) that synthesized tested as antibacterial via used differents types such as, E. coli, Bacillus subtilis, and S. aureus. The activities of these compounds with different bacteria are known by the excellent diffusion methodology applied and derivative (6) gives a more activites from other derivatives.