Antibacterial Activities of Newly Synthesized Azo Anils And its Oxalato-Bridged Binu-clear {Cu(II) and Zn(II)} Complexes

Abstract

Novel oxalato-bridged binuclear metal {Cu(II) and Zn(II)} complexes; [{(L1)M(II)}2OX] (L1= 2-({2-hydroxy-5-[(4nitrophenyl)diazenyl]benzylidene}amino)benzoic acid, OX = oxalate) and [{(L2)M(II)}2OX], (L2 = 2-{[(2hydroxyphenyl)imino]methyl}-4-[(4-nitrophenyl)diazenyl] phenol, OX = oxalate) were synthesized. Azo anils and corresponding Metal {Cu((II) and Zn(II)} complexes were characterised by Elemental Combustion System, Atomic Absorption Spectroscopy (AAS), Fourier Transform Infrared (FTIR) spectroscopy, UV-Visible, Spectroscopy and C-H-Nuclear Magnetic Resonance spectroscopy. Elemental Analyses, FTIR and UV-Vis were used for structural characterization of metal complexes and distorted octahedral geometry for M(II) complexes came into being. The antibacterial activities of azo anils ligands, oxalate ion, CuCl2.2H2O, Zn(CH3COO)2.2H2O and metal {Cu(II) and Zn(II)} complexes against gram-positive (Bacillis subtilis) and gramnegative (Escherichia coli) were evaluated. The antibacterial activities were performed to asses inhibition potential of ligand and their metal {Cu(II) and Zn(II)} complexes. The results revealed that antibacterial activities of azo anils become more pronounced when free ligands were coordinated to central metal atom.