Human Papillomavirus–Associated Oropharyngeal High-Grade Neuroendocrine Carcinoma in an Adolescent: Case Report and Review of Literature

IF 1.7 Q2 PEDIATRICS
Sara Sinno, A. Assaad, Nina Salem Shabb
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引用次数: 5

Abstract

Oropharyngeal small cell carcinomas (OPSmCC) are rare with only few case reports and case series published in the literature. More recently, an association of these tumors with human papillomavirus (HPV) infection has been detected. However, unlike oropharyngeal squamous cell carcinomas which have a better outcome when associated with HPV, OPSmCC exhibit an aggressive behavior. In this article, we report a case of tonsillar carcinoma arising in a 14-year-old boy that was associated with HPV infection. The tumor exhibited morphologic features of small cell carcinoma with no overt squamous differentiation. Yet, by immunohistochemistry, it showed diffuse and strong co-expression of both squamous and neuroendocrine markers. In addition, we present the clinicopathologic features of all the cases of OPSmCC reported in the literature for which p16 and/or HPV testing have been done.
1例青少年人乳头瘤病毒相关口咽高级别神经内分泌癌:病例报告及文献复习
口咽小细胞癌(OPSmCC)是罕见的,只有少数病例报告和病例系列发表在文献中。最近,已发现这些肿瘤与人乳头瘤病毒(HPV)感染有关。然而,与与HPV相关的口咽鳞状细胞癌有更好的结果不同,OPSmCC表现出侵袭性行为。在这篇文章中,我们报告了一个14岁男孩扁桃体癌的病例,该病例与HPV感染有关。肿瘤表现为小细胞癌的形态学特征,无明显的鳞状分化。然而,免疫组织化学显示鳞状和神经内分泌标记物的弥漫性和强共表达。此外,我们提出了所有病例的临床病理特征的OPSmCC在文献中报告的p16和/或HPV检测已经完成。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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