{"title":"Copper metabolism in the rat: effects of copper loading and copper depletion","authors":"V. Albergoni, N. Favero, G.P. Rocco","doi":"10.1016/S0006-3061(00)80151-9","DOIUrl":null,"url":null,"abstract":"<div><p>Variations of the copper distributions subsequent to copper imput changes have been studied in normal male Wistar rats. A fasting period (48 or 96 hr) produces significant variations only in the kidneys. <span>d</span>-Penicillamine administered during the fasting period induces a significant decrease of the copper content also in the liver. When injected subcutaneously. CuCl<sub>2</sub> (1–2 mg/kg body weight) stores up first in the liver and second in the kidneys (24 hr after a 2-mg/kg body-weight injection, 80% of the copper is found in the liver and 6% in the kidneys). <span>d</span>-Penicillamine administered subcutaneously to animals treated with CuCl<sub>2</sub> brings the exceeding copper of the liver to normal values within 6 hr. A prominent role of the liver and the kidneys in the copper metabolism is discussed.</p></div>","PeriodicalId":9177,"journal":{"name":"Bioinorganic chemistry","volume":"9 5","pages":"Pages 431-440"},"PeriodicalIF":0.0000,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0006-3061(00)80151-9","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioinorganic chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0006306100801519","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7
Abstract
Variations of the copper distributions subsequent to copper imput changes have been studied in normal male Wistar rats. A fasting period (48 or 96 hr) produces significant variations only in the kidneys. d-Penicillamine administered during the fasting period induces a significant decrease of the copper content also in the liver. When injected subcutaneously. CuCl2 (1–2 mg/kg body weight) stores up first in the liver and second in the kidneys (24 hr after a 2-mg/kg body-weight injection, 80% of the copper is found in the liver and 6% in the kidneys). d-Penicillamine administered subcutaneously to animals treated with CuCl2 brings the exceeding copper of the liver to normal values within 6 hr. A prominent role of the liver and the kidneys in the copper metabolism is discussed.
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