Kazuhiko Sakamoto, Masayoshi Yamauchi, Yoshihiko Maezawa, Gotaro Toda
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引用次数: 0
Abstract
Although the three GGTP mRNAs differ in their 5′ untranslated sequences (Type I–III), all give rise to the same GGTP protein. In this study, we analysed the relative abundance of the three GGTP mRNA species in alcohol-fed rat livers. The results showed that in the alcohol-fed livers, expression of type III mRNA was stronger than that of type I, while in the control livers, expression of type III mRNA was weaker than that of type I. Relative optical density of type III GGTP mRNA, using β-actin mRNA as a standard, was significantly higher in the alcohol group. In conclusion, type III GGTP mRNA of the 5′ untranslated region is strongly expressed in alcoholic liver injury.
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