Mechanistic understanding of the interaction of cells with nanostructured surfaces within the framework of biological functions

IF 2.9 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Technology Pub Date : 2023-05-23 DOI:10.1080/10667857.2023.2216529

R. Misra, A. Boriek

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引用次数: 0

Abstract

ABSTRACT The interaction of nanostructured surfaces with cells is complex and has a profound impact on the behaviour of cells by influencing their adhesion, migration, proliferation, and differentiation. Our studies highlighted the contrasting effects of nanostructured and microstructured surfaces on biological functions. Such contrasting effects include the relative influence of physical and chemical attributes of the nanoscale surface compared to the microscale counterpart. These attributes lead to an altered cellular activity at the bio-nano interface through modulating cell adhesion, proliferation of cells and synthesis of functional proteins. Physical and chemical changes induced by the nanostructure are likely to promote cell adhesion, without introducing chemical functionalities on the surface. This represents a significant advance beyond guiding the tailoring of cellular functionality at the bio-nano surface. This would yield an improved understanding of a rational design of biotic/abiotic interfaces that can promote optimal biological responses, leading to the development of new biomedical technologies.

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在生物功能的框架内，对细胞与纳米结构表面相互作用的机制理解

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来源期刊

Materials Technology 工程技术-材料科学：综合

CiteScore

6.00

自引率

9.70%

发文量

105

审稿时长

8.7 months

期刊介绍： Materials Technology: Advanced Performance Materials provides an international medium for the communication of progress in the field of functional materials (advanced materials in which composition, structure and surface are functionalised to confer specific, applications-oriented properties). The focus is on materials for biomedical, electronic, photonic and energy applications. Contributions should address the physical, chemical, or engineering sciences that underpin the design and application of these materials. The scientific and engineering aspects may include processing and structural characterisation from the micro- to nanoscale to achieve specific functionality.