Clinical retrospective analysis in delayed graft function morbidity of kidney transplantation recipients and gender factors in both donors and recipients

Abstract

Objective To explore the effects of donor/recipients’ gender on delayed graft function (DGF). Methods A retrospective analysis was performed for clinical data of donors (n=174) and recipients (n=265) during renal transplantation between May 1, 2012 and December 31, 2017. Types of China donation after citizen's death, age, last creatinine level, height, weight, body mass index (BMI) and protopathy of donors were collected. And pre-dialysis method, dialysis time, HLA mismatch, post-creatine at Day 7, whether dialysis after transplantation, height, weight and BMI of recipients were analyzed. The data were checked by t and chi square tests and P<0.05 was deemed as statistically significant. Results Donor gender had no correlation with DGF occurrence rate (P=0.689) while DGF occurrence rate among female recipients was evidently lower than that among males (P=0.036); Female recipients selected peritoneal dialysis therapy more than male recipients (P=0.023); Cerebral hemorrhage female donors were more than male donors (P=0.034); BMI (P<0.001) and postoperative creatinine (P=0.001) among female recipients were evidently lower than that among males. Conclusions DGF occurrence rate is significantly lower among female receptors than that among males after kidney transplantation. Key words: Kidney transplantation; Gender; Estrogen