The Acylation of Ketones to Form β‐Diketones or β‐Keto Aldehydes

C. Hauser, F. W. Swamer, J. T. Adams
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引用次数: 4

Abstract

Under certain conditions, a ketone having an alpha-hydrogen atom may be acylated with an ester, an acid anhydride, or an acid chloride to form a β-ketone or, when the acylating agent is a formic ester, a β-keto aldehyde. The process consists in the replacement of an alpha-hydrogen atom of the ketone by an acyl group. The reaction involves a carbon-carbon condensation. The acylation of ketones with esters has generally been effected by means of a basic reagent, such as sodium, sodium ethoxide, etc. The acylation of ketones to form β-diketones may also occur with acid anhydrides by means of an acidic reagent boron trifluoride. In this chapter the basic reagent and boron trifluoride methods of acylation are considered separately. They are compared with other methods. Keywords: acylation; ketones; β-ketones; β-aldehdyes; basic reagents; boron trifluoride; comparison of methods; experimental procedures
酮的酰化反应生成β -二酮或β -酮醛
在一定条件下,具有-氢原子的酮可与酯、酸酐或酸氯酰化,形成β-酮,或当酰化剂为甲酸酯时,形成β-酮醛。这个过程包括用酰基取代酮的-氢原子。这个反应是碳碳缩合反应。酮与酯的酰化一般是通过碱性试剂如钠、乙氧二钠等进行的。用酸性试剂三氟化硼也可使酮酰化生成β-二酮。本章分别讨论了碱性试剂法和三氟化硼酰化法。它们与其他方法进行了比较。关键词:酰化;酮;β酮;β-aldehdyes;基本的试剂;三氟化硼;方法比较;实验程序
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
4.40
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