Design and Fabrication of Gold Nanoparticles for Anti-Asthma Drug Delivery

Medical laboratory sciences Pub Date : 2020-10-14 DOI:10.22037/AMLS.V6.32580

Didar Mehrabi Nasab, A. Taheri, S. Athari

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引用次数: 3

Abstract

Background and Aim: Nanoparticle drug delivery has recently found a special place in medicine and treatment. Different nanoparticles have different capabilities and functions. Gold nanoparticles are one of the most widely used nanoparticles and have many uses in pharmaceuticals and medical purposes, including diagnostic, therapeutic, and imaging methods, and due to their unique characteristics, such as high contact surface area compared to volume. Gold nanoparticles have many advantages over other nanoparticles such as their neutral nature, stability, high diffusion property, non-toxicity, environmental compatibility, optical adjustment. Our goal is to synthesize and characterization gold nanoparticles with specific applications to produce the best delivery system of drugs to the asthmatic lung. Methods: Turkevich method has been used for the synthesis of gold nanoparticles and approving studies have been done. Results: The produced GNP has the average diameter 100-200 nm and the Z-average was 137.9 d.nm and in positive charge area. PDI for GNP was 0.358. Conclusion: In this study, we were able to produce the applicable gold nanoparticles for carrying drugs to asthmatic bronchi. Gold nanoparticles easily reach target cells due to their high dispersion power. Drug side effects are reduced when gold nanoparticles are used in conjunction with the drug for drug delivery purposes. *Corresponding Authors: Alireza Taheri, Email: taheri@ilam-iau.ac.ir; Seyyed Shamsadin Athari, Email: ss.athari@zums.ac.ir Please cite this article as: Mehrabi Nasab D, Taheri A, Athari SS. Design and Fabrication of Gold Nanoparticles for Anti-Asthma Drug Delivery. Arch Med Lab Sci. 2020;6:e4. https://doi.org/10.22037/amls.v6.32580

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抗哮喘药物递送用金纳米颗粒的设计与制备

背景与目的:纳米颗粒给药在医学和治疗中有着特殊的地位。不同的纳米颗粒具有不同的性能和功能。金纳米颗粒是使用最广泛的纳米颗粒之一，在制药和医疗领域有许多用途，包括诊断、治疗和成像方法，并且由于其独特的特性，例如与体积相比的高接触表面积。与其他纳米粒子相比，金纳米粒子具有中性、稳定性、高扩散性能、无毒性、环境相容性、光学调节性等优点。我们的目标是合成和表征具有特定应用的金纳米颗粒，以生产最佳的药物输送系统到哮喘肺。方法:采用Turkevich法合成金纳米颗粒，并进行了初步研究。结果:所得GNP的平均粒径为100 ~ 200 nm, z -平均值为137.9 d.nm，且在正电荷区。GNP的PDI为0.358。结论:本研究制备出适用于哮喘支气管药物输送的金纳米颗粒。金纳米粒子具有高分散能力，容易到达靶细胞。当金纳米颗粒与药物一起用于药物递送目的时，药物副作用会减少。*通讯作者:Alireza Taheri, Email: taheri@ilam-iau.ac.ir;Mehrabi Nasab D, Taheri A, Athari SS.用于抗哮喘药物递送的金纳米颗粒的设计和制备。中华医学杂志，2020;6:1 - 4。https://doi.org/10.22037/amls.v6.32580

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Medical laboratory sciences

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