The valorization of plum seed oil for the development of topical formulation

Abstract

The object of this paper was to utilize the plum seed oil for the preparation of the topical formulation for skin care since it can improve elasticity and prevent accelerated skin aging. Soxhlet extraction of plum seed oil was performed using n-hep-tane. The spectrophotometric methods were applied to estimate the photoprotec-tive effect and antioxidant activity of the samples. The warm-warm emulsification process was used for the preparation of topical formulation based on plum seed oil. The antioxidant activity of the plum seed oil was estimated based on the half-maximal inhibitory concentration (9.39 mg/mL). After the incorporation of the oil in the topical formulation, the IC 50 value of 9.33 mg/mL was not significantly changed. The viscosities of the topical formulation and plum seed oil were 1.56×10 6 mPa·s (at the shear rate of 5 s-1) and 60.48 mPa·s (at the shear rate of 50 s-1), respectively. Rheological analysis showed that the plum seed oil and topical formulation were Newtonian and non-Newtonian pseudoplastic fluids, respectively. The formulation adsorbed the light in the UV-Vis range so that it can be used as a w/o emulsion photoprotective cream. The cream with adequate pH value was stable and micro-biologically safe for application to the skin. Due to the use of cheaper ingredients, the formulation is acceptable and suitable for manufacturing.