Synthesis, Characterization And Antibacterial studies of some Azomethine and Azo- Compound Derivatives of selected Sulfa Drugs

Abstract

Three series of compounds have been synthesized, the first series included preparation of Schiff-bases ( NC1NC4) by condensation reaction of Salicylaldehyde with a select species of Sulfa drugs like , Sulfanilamide, Sulfadiazine , Sulfamerazine and Sulfathiazole . The second series included preparation of azo compounds (Azo1 , Azo2 , Azo3and Azo4) Which contains aldehyde group via converting Sulfathiazol, Sulfadiazine and Sulfanilamide to dizonium salt followed by coupling reaction with 2-hydroxy benzaldehyde in alkaline medium . The third series includes synthesis of azo Schiff bases (CH1-CH8) in excellent yield via condensation of different sulfa drugs and ethylene diamine . The structures of synthesized compound have been characterized by spectroscopic methods such as infrared , H-NMR and mass spectra . The purity of compound and evaluation of Rf value were determined by TLC. The above mentioned compound were studied in vitro for their antimicrobial activity against Staphylococcus aureus , Escherichia coli and fungicidal activity against Candida albicans and Aspergillusniges Also the antioxidant of some compounds have been Calculated .