Advancement of the risk prediction of hepatocellular carcinoma in patients with chronic hepatitis B virus infection

Wen-jun Chen, Junjuan Wang, Jianni Qi, Chonghai Dong, C. Qin
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引用次数: 0

Abstract

It is of important significant to predict the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus infection in clinic. Various risks scoring systems can achieve better prediction effect by integrating a variety of risk factors, but they still need to be perfected. Recent researches have found that some genotypes and genetic variations are associated with the occurrence of HCC and they can indicate the tumorigenesis of HCC. Some known or newly discovered indicators such as WFA+ -M2BP can be used to predict the occurrence of HCC independently or jointly. With the development of research, more genes, indicators as well as newly built scoring system will be utilized to predict the occurrence of HCC in clinic. Key words: Hepatitis B virus; Infection; Carcinoma, hepatocellular; Risk assessment
慢性乙型肝炎病毒感染患者发生肝细胞癌风险预测的研究进展
预测慢性乙型肝炎病毒感染患者发生肝细胞癌的风险在临床上具有重要意义。各种风险评分系统通过综合多种风险因素,可以达到较好的预测效果,但仍有待完善。近年来的研究发现,一些基因型和遗传变异与HCC的发生有关,并能提示HCC的发生。一些已知或新发现的指标如WFA+ -M2BP可单独或联合预测HCC的发生。随着研究的深入,更多的基因、指标以及新建立的评分系统将被用于临床预测HCC的发生。关键词:乙型肝炎病毒;感染;癌,肝细胞;风险评估
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