Alopecia areata and Down's syndrome

Abstract

The Down syndrome (DS) present different skin manifestations as: alopecia areata (AA), vitiligo, atopic dermatitis, pityriasis rubra pilaris, among others. AA is a chronic autoimmune inflammatory condition T-cell mediated against pilosebaceous follicle with stop of the anagen phase. AA is presented in 6–10% of patiens with DS (general population: 1.7%) and it is more frequent in women. Politherapy is more effective that monotherapy in the treatment of AA in that cases, and the prognosis is different depending of the clinical type of AA.