Blood parameters, symptoms at presentation and adverse in-hospital outcomes of COVID-19 pneumonia in patients with hypertension

IF 0.4 Q4 PERIPHERAL VASCULAR DISEASE

Arterial Hypertension Pub Date : 2021-03-15 DOI:10.5603/AH.A2021.0004

Foaad Shaghee, H. Nafakhi, Karrar Al-Buthabhak, Mohammed Alareedh, Ahmed Nafakhi, S. Kasim

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引用次数: 2

Abstract

Background: We aimed to explore the association of clinical symptoms of COVID-19 pneumonia, blood parameters on admission, and anti-hypertensive drugs with in-hospital outcomes, including length of hospital and intensive care unit (ICU) stay, receiving mechanical ventilation, degree of lung injury, and in-hospital death among patients with hypertension. Material and methods: This retrospective study conducted in patients with newly diagnosed COVID-19 pneumonia from August 20, 2020 to September 25, 2020. Results: A total of 182 patients with COVID-19 pneumonia were included in the present study. The patients were categorized into those with hypertension (n = 82) or without hypertension (n = 100). Patients on angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) showed no significant increase in the risk for all in-hospital outcomes. Old age [0.6 (0.5–2) p < 0.00], fever [0.3 (0.2–1.8), p < 0.00] and low lymphocytes percentage [0.3 (0.2–1.2), p < 0.00] were associated with increased risk for extensive lung injury. Old age [0.4 (0.1 = 0.7) p < 0.01], high neutrophil count [0.3 (0.2–2), p = 0.02] and low lymphocyte percentage [0.3 (0.1–0.7), p = 0.01] were associated with prolonged hospital stay while low lymphocytes percentage [0.7 (0.6–0.9), p < 0.00], old age [1.2 (1–1.4), p = 0.01] and fatigue [2 (1–4), p = 0.04] showed significant association with prolonged length of ICU stay. Low lymphocytes percentage [0.7 (0.6–1), p < 0.00], old age [1.1 (1–1.2), p = 0.01] and fatigue [2 (1.7–4), p = 0.02] were associated with increased risk for receiving mechanical ventilation. Risk for in-hospital death was associated with increased neutrophil percentage [1.2 (1–1.5), p = 0.01] and old age [1.1 (1–1.2), p = 0.03]. Conclusions: ARBs and ACEIs showed no significant association with adverse in-hospital outcomes. Old age, low lymphocytes percentage and high neutrophils percentage on admission were independent predictors for increased risk of in-hospital mortality and morbidity among COVID-19 pneumonia patients with hypertension.

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高血压患者COVID-19肺炎的血液参数、首发症状和不良住院结局

背景:我们旨在探讨COVID-19肺炎的临床症状、入院时血液参数和降压药与住院结局的关系，包括高血压患者住院和重症监护病房(ICU)住院时间、接受机械通气、肺损伤程度和院内死亡。材料与方法:本研究对2020年8月20日至2020年9月25日新诊断的COVID-19肺炎患者进行回顾性研究。结果:本研究共纳入182例COVID-19肺炎患者。患者分为高血压组(n = 82)和非高血压组(n = 100)。接受血管紧张素受体阻滞剂(ARBs)和血管紧张素转换酶抑制剂(ACEIs)治疗的患者在所有住院结果中的风险均未显着增加。老年[0.6 (0.5-2)p < 0.00]、发热[0.3 (0.2-1.8)，p < 0.00]、淋巴细胞百分比低[0.3 (0.2-1.2)，p < 0.00]与广泛性肺损伤风险增加相关。老年[0.4 (0.1 = 0.7)，p < 0.01]、中性粒细胞计数高[0.3 (0.2-2)，p = 0.02]、淋巴细胞百分比低[0.3 (0.1 - 0.7)，p = 0.01]与住院时间延长相关;淋巴细胞百分比低[0.7 (0.6-0.9)，p < 0.00]、老年[1.2 (1-1.4)，p = 0.01]、疲劳[2 (1-4)，p = 0.04]与住院时间延长相关。淋巴细胞百分比低[0.7 (0.6-1)，p < 0.00]、年龄大[1.1 (1-1.2)，p = 0.01]、疲劳[2 (1.7-4)，p = 0.02]与机械通气风险增加相关。院内死亡风险与中性粒细胞百分比升高[1.2 (1-1.5)，p = 0.01]和年龄[1.1 (1-1.2)，p = 0.03]相关。结论:arb和ACEIs与院内不良结局无显著相关性。老年、入院时淋巴细胞百分比低和中性粒细胞百分比高是COVID-19肺炎合并高血压患者住院死亡率和发病率风险增加的独立预测因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arterial Hypertension PERIPHERAL VASCULAR DISEASE-

CiteScore

0.70

自引率

14.30%

发文量

审稿时长

10 weeks

期刊介绍： Arterial Hypertension hereinafter referred to as ‘AH’ or ′the Journal′, is a peer-reviewed, open access journal covering broad spectrum of topics in hypertension and aiming to advance the knowledge and science of this constantly evolving field. The Journal is the official quarterly of the Polish Society of Hypertension and publishes review articles, original clinical and experimental investigations in the field of arterial hypertension, case reports, letters and editorial comments. The Journal''s content has been published predominantly in full text English since 2015.