Macrophages in Oral Tissues

Abstract

The balance between cell removal following tissue damage and new cell formation to facilitate repair has long been linked to the behaviour of inflammatory macrophages and their interactions with tissue-resident non-immune cells. The main aim of the inflammatory response is to modulate the tissue environment by removing unwanted cells and recruiting cells and soluble factors from the bloodstream to help protect the damaged tissue against infective foreign bodies. Such processes are essential for remodeling, repair, and forming new tissue in the area of damage. Macrophages play an important role in tissue repair and regeneration by exerting their effects in various tissue repair and regeneration effects by exerting their effects in various tissue repair and regeneration effects by exerting their marks in multiple ways during these processes. Current research shows that depletion of macrophages is detrimental for skin and muscle repair and whole limb regeneration [1-3]. Moreover, resident macrophages are described as regulators of inflammation levels by ‘cloaking’ microinjuries and regulating neutrophil recruitment [4-5].