Spontaneous Splenic Rupture and Capillary Leak Syndrome Due to Filgrastim Use

Abstract

ABS TRACT Filgrastim is a hematopoietic growth factor that allows blood cells to proliferate and differentiate. Spontaneous splenic rupture and capillary leak syndrome are serious side effects of filgrastim therapy. The patient was followed up in the intensive care unit after burst injury with Crush syndrome and sepsis. Filgrastim was applied due to a decrease in the white blood cell count. The patient's approach to capillary leak syndrome and spontaneous splenic rupture complications is presented. Filgrastim can cause spontaneous splenic rupture and capillary leak syndrome. Splenic should be checked periodically during the use of filgrastim.