INTESTINAL CARBOHYDRATE DIGESTION IN RAT ALLOXAN DIABETES

Abstract

Academy, Urgench, e-mail: Shirin2111@mail.ru In experiments on outbred white rats, the effect of alloxan-induced diabetes on the weight of the body and small intestine, intestinal histostructure and on the final stage of carbohydrate hydrolysis of in the small intestine was revealed. Diabetes was caused by a single intraperitoneal injection of alloxan monohydrate (170 mg / kg). Only alloxan-treated rats with the level of glucose in the blood 3 times higher than in the control group were studied. It turned out that in rats with alloxan-induced diabetes, there was a decrease in body mass (by 23.1 %) and small intestine mass (by 23.6 %). In this case, a violation of the histological structure was manifested both in mucosa and in serosa of the small intestine wall. It was expressed in a decrease in the density of cells in intestinal muscle, submucosal and mucous layers cells. Alloxan-induced diabetes also caused mucosal edema, blood capillary filling, and desquamation of epithelial cells. In addition, on the 10 th day after administration of alloxan monohydrate, there was an increase in the activity of intestinal membrane-bound disaccharidases in alloxan-induced diabetic rats. The activity of maltase, sucrase, and lactase in rats with alloxan-induced diabetes was 25.6 %, 47.2 %, and 84.6 % higher, respectively, in comparison with rats of the control group. Therefore, alloxan-induced diabetes leads to a decrease in the body and small intestine mass of rats, a violation of the histostructure of the small intestine wall as well as an increase in the specific activity of intestinal