Histopathology and Morphometric Analysis of the Internal Mammary Artery to Study the Incidence of Atherosclerosis and Its Associated Risk Factors

World Journal of Cardiovascular Surgery Pub Date : 2020-01-01 DOI:10.4236/wjcs.2020.106009

Shilpa Suresh, S. Kalpana, H. J. Kumar, S. Selvam, K. Sreedhar

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Abstract

Background: The left internal mammary artery (IMA) is widely used as a conduit for coronary revascularization. The incidence of atherosclerosis is known to be lower in the IMA than in the coronary artery. The aim of this study was to evaluate the reliability of the use of the distal section of the IMA as an anastomotic site for bypass grafting and morphometric studies of IMA in patients with proven coronary artery disease and their associated risk factors. Methods: Patients who underwent Coronary Artery Bypass Graft (CABG) from June 2010 to November 2012 were chosen in this retrospective study and the discarded distal segments of the internal mammary artery were analyzed. The potential risk factors for atherosclerosis considered were age, sex, diabetes mellitus, history of cigarette smoking, hypertension and hypercholesterolemia. The samples were analyzed for the degree of intimal thickening and atherosclerosis by calculating the percentage of Luminal Narrowing, Intimal Thickness Index (ITI) and Intima-to-Media Ratio (IMR). Results: There were seven cases of intimal hyperplasia and two cases of focal medial and intimal hyperplasia

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乳腺内动脉的组织病理学和形态计量学分析研究动脉粥样硬化的发生率及其相关危险因素

背景:左乳内动脉(IMA)被广泛用作冠状动脉血运重建术的导管。已知IMA动脉粥样硬化的发生率低于冠状动脉。本研究的目的是评估IMA远端段作为搭桥术吻合部位的可靠性，以及IMA形态计量学研究在确诊的冠状动脉疾病及其相关危险因素患者中的应用。方法:选取2010年6月至2012年11月行冠状动脉旁路移植术(CABG)的患者进行回顾性研究，分析其丢弃的乳腺内动脉远端段。动脉粥样硬化的潜在危险因素包括年龄、性别、糖尿病、吸烟史、高血压和高胆固醇血症。通过计算管腔狭窄百分比、内膜厚度指数(ITI)和内膜-中膜比(IMR)，分析样品的内膜增厚程度和动脉粥样硬化程度。结果:有7例内膜增生，2例局灶性中、内膜增生

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World Journal of Cardiovascular Surgery

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