ADD1 460W Allele Associated With Cardiovascular Disease in Hypertensive Individuals

A. Morrison, M. Bray, A. Folsom, E. Boerwinkle
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引用次数: 72

Abstract

High blood pressure is a predictor of cardiovascular disease. Hence, genes contributing to essential hypertension may play a role in the etiology of cardiovascular disease. For this reason, we examined the association between the &agr;-adducin (ADD1) G460W and G-protein &bgr;3 subunit (GNB3) 825C>T polymorphisms and the prevalence of peripheral arterial disease (PAD) and incidence of coronary heart disease (CHD) in non-Hispanic whites from the Atherosclerosis Risk in Communities (ARIC) Study. PAD prevalence was defined by an ankle-brachial index, ie, the ratio of ankle systolic blood pressure to brachial artery systolic blood pressure, of ≤0.90 for men and ≤0.85 for women. CHD incidence was determined by following the ARIC cohort for a median of 5.3 years for potential coronary events. Stratified random samples of the ARIC cohort (n=703 and n=684) were used, respectively, as the comparison groups for the PAD (n=144) and incident CHD (n=408) cases. The GNB3 825T allele and the ADD1 460W allele were not significantly associated with prevalence of PAD or incidence of CHD. However, a test of the interaction between hypertension status and the ADD1 G460W polymorphism indicated that further evaluation of the ADD1 polymorphism in only hypertensive individuals was warranted. The ADD1 460W allele was significantly associated with PAD (odds ratio [OR]: 2.61, 95% CI, 1.27–5.37, P =0.01) and CHD (hazard rate ratio [HRR]: 2.30, 95% CI, 1.20–4.42, P =0.01) in hypertensive individuals after adjustment for multiple cardiovascular disease risk factors. An interaction with hypertension in the association between the ADD1 G460W polymorphism and cardiovascular disease merits further testing in additional populations.
ADD1 460W等位基因与高血压患者心血管疾病相关
高血压是心血管疾病的前兆。因此,导致原发性高血压的基因可能在心血管疾病的病因学中发挥作用。因此,我们从社区动脉粥样硬化风险(ARIC)研究中研究了agr -内聚蛋白(ADD1) G460W和g蛋白&bgr;3亚基(GNB3) 825C>T多态性与外周动脉疾病(PAD)患病率和冠心病(CHD)发病率之间的关系。PAD患病率由踝-肱指数定义,即踝部收缩压与肱动脉收缩压之比,男性≤0.90,女性≤0.85。冠心病发病率是通过对ARIC队列中位5.3年的潜在冠状动脉事件跟踪来确定的。ARIC队列的分层随机样本(n=703和n=684)分别作为PAD (n=144)和冠心病(n=408)病例的对照组。GNB3 825T等位基因和ADD1 460W等位基因与PAD患病率或冠心病发病率无显著相关性。然而,一项关于高血压状态与ADD1 G460W多态性之间相互作用的测试表明,仅在高血压个体中进一步评估ADD1多态性是有必要的。校正多种心血管疾病危险因素后,高血压患者ADD1 460W等位基因与PAD(比值比[OR]: 2.61, 95% CI: 1.27 ~ 5.37, P =0.01)和冠心病(危险率比[HRR]: 2.30, 95% CI: 1.20 ~ 4.42, P =0.01)显著相关。ADD1 G460W多态性与心血管疾病之间是否存在与高血压的相互作用,值得在更多人群中进行进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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