Comparison of Serum Lipid Profile Changes during Treatment of Olanzapine and Risperidone

The International Journal of Life-Sciences Scientific Research Pub Date : 2017-09-01 DOI:10.21276/IJLSSR.2017.3.5.3

Amita Gupta, A. Jadhav, Vaibhav Dubey

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引用次数: 2

Abstract

Background: Several studies demonstrated relationship between dyslipidemia and various antipsychotic drugs after treatment of psychotic disorders. Our study aimed to compare the effects of commonly prescribed antipsychotic drugs Risperidone and Olanzapine on serum lipid profile of psychiatric patients. Methods: This current study was conducted on 30 psychiatric patients, divided into two groups according to the antipsychotic drug prescribed by doctor Risperidone or Olanzapine. All the patients were assessed for changes in serum lipid profile Total cholesterol (TC), Triglycerides (TG), High Density Lipoprotein (HDL-C), Low Density Lipoprotein (LDL-C), Very Low Density Lipoprotein (VLDL-C) & Risk Factors for coronary artery disease (CAD Risk Factor I &II) after 16 weeks of treatment. Results: Patients taking Olanzapine therapy were showed significant (p<0.05) increase in all lipid parameters, whereas Risperidone treated patients has shown a significant increase in serum triglyceride and VLDL-C only. Conclusion: Olanzapine therapy is strongly associated with dyslipidemia than Risperidone. Key-wordsDyslipidemia, Lipid profile, Coronary artery disease, Risk factors, Schizophrenia

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奥氮平与利培酮治疗期间血脂变化的比较

背景:一些研究证实了精神障碍治疗后血脂异常与各种抗精神病药物之间的关系。本研究旨在比较常用抗精神病药物利培酮和奥氮平对精神病患者血脂的影响。方法:本研究对30例精神病患者进行研究，根据医生开具的抗精神病药物利培酮或奥氮平分为两组。在治疗16周后，对所有患者的血脂、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、极低密度脂蛋白(VLDL-C)和冠状动脉疾病危险因素(CAD危险因素I和ii)的变化进行评估。结果:接受奥氮平治疗的患者各项血脂指标均有显著升高(p<0.05)，而接受利培酮治疗的患者仅血清甘油三酯和VLDL-C有显著升高。结论:与利培酮相比，奥氮平治疗与血脂异常有较强的相关性。关键词:血脂异常，血脂谱，冠状动脉疾病，危险因素，精神分裂症

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The International Journal of Life-Sciences Scientific Research

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