Time to Relapse and Relapse Predictors in Patients with Schizophrenia at Ayder Comprehensive Specialized Hospital, Northern Ethiopia

IF 9 Q1 PSYCHIATRY
Habtamu Endashaw Hareru, Kebede Embaye Gezae, Daniel Sisay W/tsadik, G. Gebregergs
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引用次数: 0

Abstract

Background. Rehospitalization, treatment resistance, and impairment are all possible outcomes of a schizophrenia relapse, which has a severe impact on patients, families, and the healthcare system. However, little is known regarding the time to relapse and relapse predictors in Ethiopia and in the study settings. Therefore, the aim of this study was to determine the time to relapse and relapse predictors in patients with schizophrenia at Ayder Comprehensive Specialized Hospital, Northern Ethiopia. Methods. A retrospective cohort study was carried out among 273 schizophrenia patients discharged from Ayder Comprehensive and Specialty Hospital between January 2015 and January 2019. The data was taken from the patient’s medical record and was chosen using a systematic random sampling procedure. A standardized data collection checklist was employed. The survival experiences of participants were compiled using a life table. Both univariate and multivariate Cox regression models were used for variable selection. Finally, after confirming the model’s diagnosis and assumptions, factors with a p value of less than 0.05 were declared to be statistically significant predictors of schizophrenia relapse. Results. In this study, the incidence of relapse was 2.9 per 100 person-months (PMs) and the median time to relapse of 13 months (interquartile range: 6–23 months). Being divorced ( AHR = 2.50 , 95% CI: 1.18-5.28), not adhering to treatment ( AHR = 5.7 , 95% CI: 3.03-10.74), and substance abuse ( AHR = 1.8 , 95% CI: 1.01-3.22) were risk factors for increasing schizophrenia relapse. Age ( AHR = 0.65 , 95% CI: 0.34-0.88) and length of first hospitalization ( AHR = 0.69 , 95% CI: 0.57-0.86) were factors that decreased schizophrenia relapse. Conclusion and Recommendation. In this study, out of 100 patients with schizophrenia followed up for a month, three had a relapse, and the highest risk factor for relapse was treatment nonadherence, followed by being divorced and substance misuse. As a result, it is advised that all parties involved focus on early detection and taking preventive measures against schizophrenia relapse, as well as providing regular psychoeducation about the significance of treatment adherence and connecting patients with substance misuse to substance rehabilitation centers.
埃塞俄比亚北部艾德尔综合专科医院精神分裂症患者的复发时间和复发预测因素
背景。再住院、治疗抵抗和精神障碍都是精神分裂症复发的可能结果,这对患者、家庭和卫生保健系统都有严重影响。然而,在埃塞俄比亚和研究环境中,关于复发时间和复发预测因素知之甚少。因此,本研究的目的是确定埃塞俄比亚北部艾德尔综合专科医院精神分裂症患者的复发时间和复发预测因素。方法。对2015年1月至2019年1月从艾德尔综合专科医院出院的273例精神分裂症患者进行回顾性队列研究。数据取自患者的医疗记录,并采用系统的随机抽样程序进行选择。采用标准化的数据收集清单。参与者的生存经验是用生命表汇编的。采用单因素和多因素Cox回归模型进行变量选择。最后,在确认模型的诊断和假设后,p值小于0.05的因素被宣布为精神分裂症复发的有统计学意义的预测因子。结果。在本研究中,复发发生率为2.9 / 100人月(PMs),中位复发时间为13个月(四分位数范围:6-23个月)。离婚(AHR = 2.50, 95% CI: 1.18-5.28)、不坚持治疗(AHR = 5.7, 95% CI: 3.03-10.74)和药物滥用(AHR = 1.8, 95% CI: 1.01-3.22)是增加精神分裂症复发的危险因素。年龄(AHR = 0.65, 95% CI: 0.34-0.88)和首次住院时间(AHR = 0.69, 95% CI: 0.57-0.86)是减少精神分裂症复发的因素。结论和建议。在这项研究中,对100名精神分裂症患者进行了一个月的随访,其中3人复发,复发的最高风险因素是不坚持治疗,其次是离婚和药物滥用。因此,建议各方关注精神分裂症的早期发现和预防措施,以及定期提供关于坚持治疗的重要性的心理教育,并将药物滥用患者与药物康复中心联系起来。
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来源期刊
Mental Illness
Mental Illness PSYCHIATRY-
CiteScore
1.10
自引率
0.00%
发文量
3
审稿时长
10 weeks
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