Alessandra Gambineri, Daniela Laudisio, Chiara Marocco, Stefano Radellini, Annamaria Colao, Silvia Savastano, on behalf of the Obesity Programs of nutrition, Education, Research and Assessment (OPERA) group
{"title":"Female infertility: which role for obesity?","authors":"Alessandra Gambineri, Daniela Laudisio, Chiara Marocco, Stefano Radellini, Annamaria Colao, Silvia Savastano, on behalf of the Obesity Programs of nutrition, Education, Research and Assessment (OPERA) group","doi":"10.1038/s41367-019-0009-1","DOIUrl":null,"url":null,"abstract":"Obesity is associated with infertility in women through multiple and complex mechanisms. Briefly, the adipose tissue through the production of many factors, such as leptin, free fatty acids (FFA), and cytokines may affect both ovarian and endometrium functions, with a final alteration in oocyte maturation and endometrial epithelium receptivity. In addition, through the development of peripheral insulin resistance obesity produces a condition of functional hyperandrogenism and hyperestrogenism that contribute to produce anovulation and to reduce endometrial receptivity and, therefore participate to cause infertility. Weight loss is able to restore fertility in most cases, but there are no practical indications to guide the clinician to choice the best method among increased physical activity, diet, drugs, and bariatric surgery.","PeriodicalId":14202,"journal":{"name":"International journal of obesity supplements","volume":"9 1","pages":"65-72"},"PeriodicalIF":0.0000,"publicationDate":"2019-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/s41367-019-0009-1","citationCount":"64","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of obesity supplements","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s41367-019-0009-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 64
Abstract
Obesity is associated with infertility in women through multiple and complex mechanisms. Briefly, the adipose tissue through the production of many factors, such as leptin, free fatty acids (FFA), and cytokines may affect both ovarian and endometrium functions, with a final alteration in oocyte maturation and endometrial epithelium receptivity. In addition, through the development of peripheral insulin resistance obesity produces a condition of functional hyperandrogenism and hyperestrogenism that contribute to produce anovulation and to reduce endometrial receptivity and, therefore participate to cause infertility. Weight loss is able to restore fertility in most cases, but there are no practical indications to guide the clinician to choice the best method among increased physical activity, diet, drugs, and bariatric surgery.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
