Population-based Rate and Patterns of Diplopia in Giant Cell Arteritis

IF 0.8 Q4 CLINICAL NEUROLOGY

Neuro-Ophthalmology Pub Date : 2021-08-20 DOI:10.1080/01658107.2021.1965627

Clara M. Castillejo Becerra, C. Crowson, M. Koster, K. Warrington, M. Bhatti, John J. Chen

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引用次数: 3

Abstract

ABSTRACT Giant cell arteritis (GCA) is the most common vasculitis in older adults with permanent vision loss as a feared complication. Diplopia has been reported in a small percentage of patients with visual manifestations. The goal of this study was to determine the population-based rates and patterns of binocular diplopia from GCA. The Rochester Epidemiology Project (REP), a medical records linkage system was used to identify all residents of Olmsted County, Minnesota, USA, diagnosed with GCA between January 1, 1950 and December 31, 2019. Medical records were then reviewed to identify patients with binocular diplopia from GCA. There were 301 incident cases of GCA from 1950 to 2019. Fourteen (5%) patients presented with binocular diplopia. Of these 14 patients, nine (3%) had constant diplopia and five (2%) had transient diplopia. Among patients with constant diplopia, cranial nerve VI involvement was suspected in four (44%) cases. Systemic symptoms and inflammatory markers were similar in patients with and without diplopia. There was no difference in the rate of anterior ischaemic optic neuropathy between the two groups (7% vs. 7%, p = 1.00). In conclusion, this population-based study showed that binocular diplopia was present in 5% of patients with GCA, which could either be transient or constant. GCA patients with diplopia had similar systemic manifestations and risk of vision loss as GCA patients without diplopia.

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巨细胞动脉炎复视的人群发生率和模式

巨细胞动脉炎(GCA)是老年人永久性视力丧失中最常见的血管炎，是一种令人恐惧的并发症。复视在少数有视觉表现的患者中有报道。本研究的目的是确定以人群为基础的GCA双目复视的发生率和模式。罗切斯特流行病学项目(REP)是一个医疗记录链接系统，用于识别1950年1月1日至2019年12月31日期间美国明尼苏达州奥姆斯特德县诊断为GCA的所有居民。然后回顾医疗记录以确定GCA患者的双眼复视。1950 - 2019年共发生GCA 301例。14例(5%)患者表现为双眼复视。在这14例患者中，9例(3%)为持续性复视，5例(2%)为短暂性复视。在持续性复视患者中，有4例(44%)怀疑脑神经VI受累。复视患者和非复视患者的全身症状和炎症指标相似。两组前路缺血性视神经病变发生率无差异(7% vs. 7%， p = 1.00)。总之，这项基于人群的研究表明，5%的GCA患者存在双眼复视，可能是短暂的，也可能是持续的。伴有复视的GCA患者与无复视的GCA患者具有相似的全身性表现和视力丧失的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuro-Ophthalmology 医学-临床神经学

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Neuro-Ophthalmology publishes original papers on diagnostic methods in neuro-ophthalmology such as perimetry, neuro-imaging and electro-physiology; on the visual system such as the retina, ocular motor system and the pupil; on neuro-ophthalmic aspects of the orbit; and on related fields such as migraine and ocular manifestations of neurological diseases.