Frequency and Antimicrobials Susceptibility Pattern of Staphylococcus aureus Associated with Wound Infections in Surgery Department, Wad Madani Teaching Hospital, Sudan

Pharmacology & Pharmacy Pub Date : 2021-01-01 DOI:10.4236/pp.2021.1212028

S. Yousif, A. Abakar, B. Y. Nour, Salma Ibrahim, O. A. Elhasan, M. A. Yousif, Sitelbanat Yassin, Hajer M. Hussien, Mohamed Taj-Eldin, Elhadi A. Ahmed

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引用次数: 1

Abstract

Background: Most community and hospital acquired infections are due to Staphylococcus aureus, these infections involve both local suppurative and systemic conditions. There is an increase in the incidence rates of acquiring resistant strains of Staphylococcus aureus in hospitals and community in Sudan. This study aims to detect frequency of Staphylococcus aureus isolated from surgical-sites infections (SSIs) and traumatic wounds, and to determine susceptibility to commonly used drugs. Methods: Prospective cross-sectional laboratory based study was followed, 250 patients admitted to Surgery Departments at Wad Madani Teaching Hospitals during 2019 and 2020 were recruited; with clinical manifestation of SSIs and or/traumatic wounds. Swab sample was taken from each participant and incubated aerobically on mannitol salt agar. Biochemical tests and 16rRNA gene used for Staphylococcus aureus identification. Antimicrobial susceptibility was accomplished using Kirby Bauer disc diffusion technique. Results: Infection rate of wounds in males and females equal 71% (17/250) and 29% (73/250), while infection rate in the age group of 41 to 60 years was the highest with percentage of 49% (122/250). Staphylococcus aureus constituting 76% (181/238) as predominant isolates. SSIs isolates of Staphylococcus aureus were highly resistant to tested antimicrobials. Meropeneme was the drug of choice with sensitivity of 88% and 100% for SSIs and traumatic wounds isolates respectively. Conclusion: In hospitals and community Staphylococcus aureus remain the most common How to cite this paper: Yousif, S.M., Abakar, A.D., Nour, B.Y.M., Ibrahim, S.O., Elhasan, O.M.A., Yousif, M.A., Yassin, S., Hussien, H.M., Taj-Eldin, M. and Ahmed, E.A. (2021) Frequency and Antimicrobials Susceptibility Pattern of Staphylococcus aureus Associated with Wound Infections in Surgery Department, Wad Madani Teaching Hospital, Sudan. Pharmacology & Pharmacy, 12, 334-343. https://doi.org/10.4236/pp.2021.1212028 Received: November 3, 2021 Accepted: December 27, 2021 Published: December 30, 2021 Copyright © 2021 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access

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苏丹Wad Madani教学医院外科与伤口感染相关的金黄色葡萄球菌频率及药物敏感性分析

背景:大多数社区和医院获得性感染是由金黄色葡萄球菌引起的，这些感染包括局部化脓性和全身性感染。在苏丹的医院和社区中，获得耐药金黄色葡萄球菌菌株的发生率有所增加。本研究旨在检测手术部位感染(ssi)和创伤伤口分离的金黄色葡萄球菌的频率，并确定对常用药物的敏感性。方法:采用前瞻性横断面实验室研究，招募2019年至2020年在Wad Madani教学医院外科住院的患者250例;临床表现为ssi和/或创伤性伤口。从每个参与者身上取拭子样本，在甘露醇盐琼脂上进行有氧培养。生化试验及16rRNA基因用于金黄色葡萄球菌鉴定。采用Kirby Bauer盘片扩散技术进行药敏试验。结果:男女伤口感染率分别为71%(17/250)和29%(73/250)，其中41 ~ 60岁年龄组感染率最高，为49%(122/250)。金黄色葡萄球菌占76%(181/238)，是优势菌株。金黄色葡萄球菌的ssi分离株对所测试的抗菌素具有高度耐药性。美罗培尼是首选药物，对ssi和创伤分离物的敏感性分别为88%和100%。结论:在医院和社区中，金黄色葡萄球菌仍然是最常见的。本文如何引用:Yousif, S.M, Abakar, A.D, Nour, B.Y.M, Ibrahim, S.O, Elhasan, O.M.A, Yousif, M.A, Yassin, S.， Hussien, h.m.， Taj-Eldin, M. and Ahmed, E.A.(2021)苏丹Wad Madani教学医院外科伤口感染相关金黄色葡萄球菌的频率和抗菌药物敏感性模式。药理学与药学，12,334-343。https://doi.org/10.4236/pp.2021.1212028收稿日期:2021年11月3日收稿日期:2021年12月27日出版日期:2021年12月30日版权所有©作者与科研出版公司。本作品采用知识共享署名国际许可协议(CC BY 4.0)。http://creativecommons.org/licenses/by/4.0/开放获取

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Pharmacology & Pharmacy

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