Relationship between symptoms of dyspnea, cough and chromosomal imbalance

Abstract

Objectives: Genetic instability is one of the basic reasons for the survival. In this study, a very high genetic imbalance that is inconsistent with cough and life can not be explained with our current genetic information. Materials and methods: We performed cytogenetic analysis by G-banding in an adult girl, aged 23 years, with hundreds of chromosomal abnormalities (CAs). While she has been evaluating for diffuse parenchymal lung disease (DPLD), was considered to have a possible genetic disorder. Results: We observed that there was at least one or more structural and/or numerical CAs in a cell of a person. The numerical and structural aberrations were found in 94.3% of cells analyzed. These CAs were a very serious and very important genetic instability. However, these hundreds of CAs had reflected to clinic appearence with the symptom of dyspnea, cough for the last 5 months, atypical facial and growth retardation. Conclusion: There is a relationship between chromosome damage and symptoms of dyspnea, cough. We are in an inappropriate situation with normal mitosis. It needs to be investigated and explained. *Correspondence to: Osman Demirhan, Department of Medical Biology and Genetics, Faculty of Medicine, Çukurova University, 01330 Balcalı-Adana, Turkey, Tel: 903223387140, Fax: 90-322-3386572, E-mail: osdemir@cu.edu.tr