Seroprevalence of Human Cytomegalovirus Infection among HIV Patients in Khartoum State

Abstract

Background: Human Cytomegalovirus (HCMV) is one of the opportunistic infections associated with significantly high morbidity and mortality among patients living with immunodeficiency syndrome. CMV has been reported to enhance HIV replication and accelerate the progre ssion of HIV infection to AIDS. Aim: The aim of this study was to determine the prevalence of HCMV among HIV patients in Khartoum State, Sudan, during the period April to July 2018. Methods: The study was carried out in Khartoum State, Sudan. A total of 9 2 HIV sero - positive cases were included. HCMV IgG and IgM antibodies were detected using Enzyme Linked Immune Sorbent Assay. Results: Among 92 HIV positive samples, 91 (99%) were found positive for HCMV - IgG while 3 samples (3.2%) were positive for HCMV - I gM. Conclusion: In Sudan, the existence of HCMV in patients with HIV infection was confirmed by using ELISA. These findings indicate that CMV is hyper-endemic in HIV seropositive patients in Khartoum, Sudan.