Research progress of heme oxygenase-1 and chronic obstructive pulmonary disease

Abstract

Chronic obstructive pulmonary disease (COPD) is a preventable and treatable respiratory disease characterized by persistent airflow limitation.Its mechanism has not yet been fully clarified.In recent years, many studies have shown that oxidative stress and gene polymorphism play a very important role in its development.Heme oxygenase-1 (HO-1) is an important oxygen reductase in the body and is closely related to COPD.This article reviews the relationship between the occurrence, development, treatment and prognosis of HO-1 and COPD, in order to provide new ideas for the diagnosis, treatment and management of COPD. Key words: Pulmonary disease, chronic obstructive; Genes, duplicate; Heme oxygenase-1