OVERALL LONG-TERM (TEN-YEAR) SURVIVAL OF PATIENTS WITH GASTRIC CANCER WITH POSITIVE AND NEGATIVE CYTOLOGICAL PERITONEAL WASHINGS

Abstract

Gastric cancer prognosis remains problematic because of still high recurrence of peritoneal metastasis. Therefore, the detection of tumour cells in the abdominal cavity is of great prognostic value. The study aims to compare groups of patients with positive and negative cytological washings from the peritoneum in the 10-year term. We used data from patients with morphologically verified gastric cancer, who received radical surgical treatment in the abdominal oncology department of the Sverdlovsk Regional Oncologi Dispensary, in the period from 2008 to 2011. The sample included 142 cases. The patients were divided into 2 groups according to the presence of a positive (Cyt +) or negative (Cyt-) washout from the peritoneum, 58 and 84 cases accordingly. Intra-abdominal hyper thermo chemo perfusion (HIPEC) was performed in 20 patients from the (Cyt +) group, and 38 patients received adequate surgical treatment. Long-term 10-year results were analysed in 119 patients. We assessed the 10-year survival rate depending on the depth of invasion (≥T3), patients (Cyt +) and HIPEC was 8%. However, the 10-year survival rate without the use of HIPEC was not achieved. In our study, the presence of (Cyt +), determines the decrease in survival rate in the 10-year period, regardless of (≥T3); (G1-G2) and (G3-G4).The use of the HIPEC technique in patients (Cyt +) determines an increase in survival from 0% to 8% and a follow-up period from 50 months to 120 months.