Assessment of Anti–Gliadin (IgA & IgG), Thyroid Stimulating Hormon and Growth Hormon Level in Celiac Disease Patients in Erbil City – IRAQ

Abstract

Celiac disease (CD) is an autoimmune human leukocyte antigen HLA–linked enteropathy that develop upon ingestion of gluten containing diet, withdiarrhea, malabsorption and weight loss as a major presentation.The disease is closely linked to a number of extra intestinal disorderespecially endocrine diseases. This study aimed to assess level of thyroidstimulation hormone (TSH) and growth hormone (GH) level in patients with newlydiagnosed (ND) CD and on gluten free diet (GFD)A total of 26/50 newly diagnosed celiac disease patients and 20 on GFDdiagnosed clinically and confirmed serologically using anti-gliadin IgA and IgG(IgA for diagnosis newly diagnosed and IgG for diagnosis of patients on GFD)were subjected to TSH and GH level assessment.The anti-gliadin IgA and IgG were positive in 82% with celiac patients and80% on GFD patients. Among children , 82.14% of newly diagnosed and 85.71%on GFD were IgA and IgG anti-gliadin seropositive, while in adults, 81.82% and76.92 % of newly diagnosed and on GFD were IgA and IgG anti-gliadinseropositive respectively. The results revealed elevated TSH level in sera of 80.77% and 30% of CDand on GFD patients respectively; meanwhile GH level was low in 73.07% and10% of CD and GFD patients respectively. The frequency CD patients revealedTSH elevation and low GH in the same patient was 69.23 % and 10% in CD and onGFD patients respectively.As a result, the present study delineated simultaneous occurrence and linkagebetween CD disease and subclinical hypothyroidism. Beside assessment of GHlevel in CD patients is necessary as marker for disorder of pituitary gland, possiblyof autoimmune origin.In newly diagnosed and patients on GFD patients, no significant correlation existsbetween anti-gliadin antibodies, TSH & GH level. Meanwhile significantcorrelation was found between TSH & GH in ND (r= - 0.568, P=0.002) & GFD (r=- 0.702, P= 0.001).