New Tacrine derivatives and Tacrine-Chitosan systems for application against degenerative diseases

Abstract

Our research focuses on the synthesis of new tacrine derivatives with an expected similar or higher inhibitory activity of AChE and BuChE than commercial tacrine and hybrids tacrine-chitosan derivatives with tunable biological properties by reaction of the biopolymer with the different tacrine derivatives synthesized. All new compounds have been characterized by NMR techniques both in solution and in solid state.