Anxiolytic and hypnotic effects of ethanolic root extract of Carica papaya in mice

G. Kiranmayi
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Abstract

Aim: The aim of the present study is to evaluate the anxiolytic and hypnotic effects of ethanolic root extract of Carica papaya in mice. Materials and Methods: Anxiolytic activity was observed using behavior paradigms such as elevated plus maze, Ymaze, open field test, and hole board apparatus, while the hypnotic activity was assessed by sodium pentobarbital-induced hypnosis in mice. In elevated plus maze and Y maze, the animals were treated with the extract at dose (75 and 150 mg/kg) po for 7 days and were observed on 7th day of treatment. Anxiolytic activity using open-field apparatus and in sodium pentobarbital-induced hypnosis, the effects were observed on day 1, 7, 15, and 30 days of treatment. Results and Discussion: In the elevated plus maze, there was an increase in the number of entries and time spent in the open arm. In Y maze decrease in the number of visits to three arms was observed. In the hole board test observed increase in the number of head dippings. In sodium pentobarbital-induced hypnosis, there is a significant increase in the duration of sleep and a decrease in the latency of sleep. The anxiolytic and hypnotic effects were substantially greater at dose 150 mg/kg in comparison to dose 75 mg/kg. Conclusion: The results obtained indicate that ethanolic C. papaya root extract might have significant anxiolytic and hypnotic activity.
番木瓜乙醇根提取物对小鼠的抗焦虑催眠作用
目的:研究番木瓜乙醇根提取物对小鼠的抗焦虑和催眠作用。材料与方法:采用升高+迷宫、Ymaze、空地实验、孔板实验等行为范式观察小鼠抗焦虑活性,采用戊巴比妥钠诱导催眠评估小鼠催眠活性。在升高正迷宫和Y迷宫中,分别以75和150 mg/kg po剂量给药7 d,第7天进行观察。在开放场仪和戊巴比妥钠诱导催眠下,观察治疗第1、7、15和30天的抗焦虑活性。结果与讨论:在高架+迷宫中,进入的次数和在张开的手臂上花费的时间都有所增加。在Y迷宫中,观察到三个臂的访问次数减少。在孔板试验中观察到头部浸出次数增加。在戊巴比妥钠诱导的催眠中,睡眠持续时间明显增加,睡眠潜伏期明显减少。与75 mg/kg剂量相比,150 mg/kg剂量的抗焦虑和催眠作用明显更大。结论:乙醇番木瓜根提取物具有显著的抗焦虑、催眠作用。
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