Paracetamol-Induced Generalized Bullous Fixed Drug Eruption Proven by Oral Provocation Test

Abstract

ated, delayed type of drug reactions.1 FDEs are characterized by the appearance of a single or multiple sharply demarcated violaceous erythematous plaques that may blister and is often associated with pruritus.1 The diagnostic characteristic is its recurrence at previously affected sites.1 The lesions usually occur on the hip, lower back, proximal extremities, lips, face, and genitals.2 The lesions usually develop from 30 minutes to eight hours time after taking the responsible drug.3 Generalized bullous FDE (GBFDE) is an extremely rare form of FDE characterized by wide spread red or brown macules or plaques with overlying large flaccid bullae.4 We herein report a case of a GBFDE following the use of paracetamol.