NEW, GREEN AND MINIATURIZED ANALYTICAL METHOD FOR DETERMINATION OF CEFADROXIL MONOHYDRATE IN CAPSULES

Drug Analytical Research Pub Date : 2019-07-17 DOI:10.22456/2527-2616.91086

Bianca Aparecida de Marco, A. Kogawa, H. R. Salgado

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引用次数: 5

Abstract

Cefadroxil, an oral antimicrobial, presents few techniques optimized for the reduction of solvents and toxic residues and/or non-use of them. So, a quantitative, new and miniaturized method for determination of cefadroxil monohydrate in capsules has been developed and validated by spectrophotometric method in the visible region according to the international guidelines. The analyzes were performed using microplates containing 96 wells, 1 % of phenolphthalein and sodium hydroxide 0.1 M as reagent at 552 nm. The method was (i) linear in the range of 15-115 µg mL-1, (ii) selective when comparing standard, sample, adjuvants and color reagent, (iii) precise with deviations below 4 %, (iv) accurate when comparing the proposed method with the HPLC method, (v) robusts by making small and deliberate modifications to the method, (vi) besides being fast, low cost, eco-friendly and generates minimal amount of waste. The method can be applied to the routine quality control of cefadroxil monohydrate in capsules and an effective and accessible alternative that contemplates the concepts of current and sustainable green analytical chemistry.

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新型、绿色、微型分析方法测定胶囊中一水头孢地诺酯的含量

头孢地螺醇是一种口服抗菌剂，很少有技术优化用于减少溶剂和有毒残留物和/或不使用它们。为此，根据国际标准，建立了一种定量、小型化的胶囊中一水头孢地诺酯含量测定新方法，并在可见区采用分光光度法进行了验证。采用含有96孔的微孔板，以1%的酚酞和0.1 M的氢氧化钠为试剂，在552nm处进行分析。该方法(i)在15-115µg mL-1范围内呈线性，(ii)在比较标准品、样品、佐剂和显色剂时具有选择性，(iii)精确，偏差小于4%，(iv)与HPLC法比较准确，(v)通过对方法进行小而仔细的修改而稳定，(vi)除了快速，低成本，环保和产生的废物最少。该方法可用于头孢地诺酯一水胶囊的常规质量控制，是一种考虑当前和可持续绿色分析化学概念的有效和可获得的替代方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Drug Analytical Research

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