Complete Posterior Vitreous Detachment Reduces the Need for Treatment of Diabetic Macular Edema.

Regulatory Peptides Pub Date : 2019-11-01 DOI:10.3928/23258160-20191031-13

William Anderson, Kisha Piggott, Yicheng K Bao, Hang Pham, Sweta Kavali, Rithwick Rajagopal

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Abstract

Background and objective: To evaluate the vitreomacular interface and its relation to treatment burden for diabetic macular edema (DME) in patients without overt vitreomacular traction (VMT).

Patients and methods: A retrospective cohort study of 494 eyes from 274 patients who had macular spectral-domain optical coherence tomography (SD-OCT) and did not have proliferative diabetic retinopathy, DME, or VMT at the initial visit. Posterior vitreous detachment (PVD) was categorized at the initial visit into five stages (0-4) using SD-OCT parameters alone.

Results: Two of 34 eyes (6.9%) presenting with a complete PVD required DME treatment during follow-up, whereas 144 of 460 eyes (31.3%) without a complete PVD at baseline required treatment (P = .001, Chi-squared). After adjusting for age, ethnicity, gender, and HbA1c, complete PVD at baseline was associated with a significant reduction in risk of DME therapy (hazard ratio: 0.18; 95% confidence interval, 0.05-0.73; P = .02).

Conclusion: Complete PVD is independently associated with a reduced need for DME treatment. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:e266-e273.].

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完全玻璃体后脱离可减少糖尿病黄斑水肿的治疗需求。

背景和目的评估无明显玻璃体白膜牵引（VMT）的糖尿病黄斑水肿（DME）患者的玻璃体白膜界面及其与治疗负担的关系：对274名患者的494只眼睛进行回顾性队列研究，这些患者在初诊时接受了黄斑光谱域光学相干断层扫描（SD-OCT）检查，且没有增殖性糖尿病视网膜病变、DME或VMT。初次就诊时，仅使用 SD-OCT 参数将后玻璃体脱落（PVD）分为五个阶段（0-4）：结果：34 只出现完全玻璃体脱落的眼睛中有 2 只（6.9%）需要在随访期间接受 DME 治疗，而基线时未出现完全玻璃体脱落的 460 只眼睛中有 144 只（31.3%）需要接受治疗（P = .001，Chi-squared）。调整年龄、种族、性别和 HbA1c 后，基线时完全 PVD 与 DME 治疗风险的显著降低相关（危险比：0.18；95% 置信区间：0.05-0.73；P = .02）：结论：完全的 PVD 与减少 DME 治疗需求有独立联系。[Ophthalmic Surg Lasers Imaging Retina.］

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Regulatory Peptides 医学-内分泌学与代谢

自引率

0.00%

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审稿时长

2 months

期刊介绍： Regulatory Peptides provides a medium for the rapid publication of interdisciplinary studies on the physiology and pathology of peptides of the gut, endocrine and nervous systems which regulate cell or tissue function. Articles emphasizing these objectives may be based on either fundamental or clinical observations obtained through the disciplines of morphology, cytochemistry, biochemistry, physiology, pathology, pharmacology or psychology.