Association between Bone Metabolism and the Severity of Chronic Heart Failure in Chinese Elderly Men and Women

IF 0.3 4区医学 Q4 GERIATRICS & GERONTOLOGY

International Journal of Gerontology Pub Date : 2020-08-01 DOI:10.6890/IJGE.202008_14(3).0015

X. Lv, Wenyan Gao, Guo-Fu Wang, B. Jia, Jing Zhang, Jirong Wang, Wenmin Xing, Jing Yan

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引用次数: 0

Abstract

Background: The role of bone metabolism markers for identifying the severity of chronic heart failure (CHF) in elderly adults had not been comprehensively investigated. Methods: 335 elderly patients (mean age 83.98 years, women 36.72%) were divided into mild CHF (NYHA class I+II) group and severe CHF (NYHA class III+IV) group. We performed a binary logistic regression analysis to identify the independent association of bone metabolism markers with the severity of CHF. Besides, we used ROC curve to explore the predictability of bone metabolism markers on CHF severity. Results: BMD levels of femoral neck in severe CHF group were significantly lower than that in mild CHF group with no gender difference. However, CTX-I, OC, PINP, ALP and PTH levels were significantly increased only in women with severe CHF. CTX-I (OR = 1.003, p = 0.008) was identified as an independent influencing factor positively associated with the severity of CHF in women after controlling for covariates. The predictability of CTX-I, OC, PINP and ALP for CHF severity was superior to NT-proBNP. Conclusion: The association between bone metabolism and CHF severity varied by genders. Bone metabolism markers, especially the CTX-I, might be a possible risk marker associated with CHF severity independent of NT-proBNP in women.

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骨代谢与中国老年男性和女性慢性心力衰竭严重程度的关系

背景:骨代谢标志物在识别老年人慢性心力衰竭(CHF)严重程度中的作用尚未得到全面研究。方法:335例老年患者(平均年龄83.98岁，女性36.72%)分为轻度CHF (NYHA I+II级)组和重度CHF (NYHA III+IV级)组。我们进行了二元逻辑回归分析，以确定骨代谢标志物与慢性心力衰竭严重程度的独立关联。此外，我们使用ROC曲线探讨骨代谢指标对CHF严重程度的可预测性。结果:重度CHF组股骨颈BMD水平明显低于轻度CHF组，且无性别差异。然而，ctx - 1、OC、PINP、ALP和PTH水平仅在严重CHF患者中显著升高。在控制协变量后，ctx - 1 (OR = 1.003, p = 0.008)被确定为与女性CHF严重程度呈正相关的独立影响因素。CTX-I、OC、PINP和ALP对CHF严重程度的可预测性优于NT-proBNP。结论:骨代谢与CHF严重程度的关系因性别而异。骨代谢标志物，特别是ctx - 1，可能是独立于NT-proBNP的女性CHF严重程度相关的风险标志物。

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来源期刊

International Journal of Gerontology 医学-老年医学

CiteScore

0.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal aims to publish original research and review papers on all fields of geriatrics and gerontology, including those dealing with critical care and emergency medicine. The IJGE aims to explore and clarify the medical science and philosophy in all fields of geriatrics and gerontology, including those in the emergency and critical care medicine. The IJGE is determined not only to be a professional journal in gerontology, but also a leading source of information for the developing field of geriatric emergency and critical care medicine. It is a pioneer in Asia. Topics in the IJGE cover the advancement of diagnosis and management in urgent, serious and chronic intractable diseases in later life, preventive medicine, long-term care of disability, ethical issues in the diseased elderly and biochemistry, cell biology, endocrinology, molecular biology, pharmacology, physiology and protein chemistry involving diseases associated with age. We did not limit the territory to only critical or emergency condition inasmuch as chronic diseases are frequently brought about by inappropriate management of acute problems.