Hormone-related proteomic and functional variations in human nonfunctional pituitary adenomas

Abstract

Human nonfunctional pituitary adenoma (NFPA) is a common intracranial tumor and difficult in early-stage diagnosis due to barely hormone-elevation in blood, with different hormone-expressed subtypes. Hormone-related proteomic and functional variations in NFPAs were revealed with two-dimensional electrophoresis, mass spectrometry, bioinformatics, and systems biology. The proteomic and functional profiles were constructed from a follicle-stimulating hormone (FSH)-positive NFPA tissue. The variations in proteome and molecular network were analyzed among four subtypes of NFPAs (NF-, LH+, FSH+ and LH/FSH+). Those data regarding proteomic and functional variations benefit in-depth understanding of molecular mechanisms in the processes of NFPA formation and discovery of the effective biomarkers and therapeutic targets for personalized prediction, prevention, and therapy, and precision medicine practices in NFPAs.