The net water uptake by excitable cells is a primary mechanism for pain signal generation

Abstract

An abnormal (hyper) excitation of neuronal and muscle membranes, which is transmitted into central nervous system (CNS) and generates pain sensation. Hence, the bioequivalence of the water by the cells in the body determines the phenomenon. Since pain can be generated by different phenomena, starting from mechanical damage to the breakdown of different metabolic pathways, there must be a common cellular mechanism through which various physical, chemical and metabolic factors generate abnormal excitation of cell membrane. It is known that pain sensation can be changed upon the effect of extremely weak chemical and physical signals, having intensity even less than thermal threshold and non-linear dose-dependent character.