Correlationship between oxidative damage and IP-10, Rantes in lung cancer patients

Abstract

Objective To investigate the possible associations of oxidative damage and serum chemokines, IFN-γ-inducible protein-10 (IP-10), Regulated on activation normal T-cell-expressed and secreted (Rantes) in lung cancer patients. Methods Blood samples were collected from 52 lung cancer patients as lung cancer group, 34 chronic bronchitis patients as the ratio of group and 20 healthy controls as healthy control group Who were admitted to the department of geriatrics of Dongying district people′s hospital from February 2018 to February 2019.The activities of serum superoxide dismutase (SOD) were measured by xanthine oxidase method, the levels of malondialdehyde (MDA) were detected by thiobarbituric acid colorimetric method (TBA) and the serum levels of IFN-γ-inducible protein-10 (IP-10), regulated on activation normal T-cell-expressed and secreted (Rantes) were measured by enzyme-linked immunosorbent assay (ELISA). Linear correlation analysis was used to analyze the correlationship. Results The activities of serum SOD were significantly lower in lung cancer group compared to the ratio of group and healthy control group (F=29.681, P<0.05). while the levels of MDA were significantly higher in lung cancer group compared to the ratio of group and healthy control group (F=61.151, P<0.05). In addition, the activities of SOD were correlated to clinical stages in patients with lung cancerⅠ~Ⅳ period, the difference was statistically significant (F=11.734, P<0.05). The levels of IP-10 and Rantes were higher in lung cancer group than the ratio of group and healthy control group (F=22.115, 13.181, P<0.05). The levels of IP-10 and Rantes were negatively correlated with the activities of SOD (r=-0.309, -0.376, P=0.017, 0.034), while positively correlated with the levels of MDA (r=0.357, P=0.021). Conclusions Strong associations were found between chemokines and oxidative stress which participated in the pathogenesis of lung cancer. Key words: Lung neoplasms; Superoxide dismutase; Malondialdehyde; IFN-γ-inducible protein-10; Regulated on activation normal T-cell-expressed and secreted