Evaluation of human peptide/histidine transporter 1 (hPHT1/SLC15A4) function: transport kinetics utilizing a HPHT1 shRNA stably transfected knockdown in the hCMEC/D3 blood-brain barrier cell line
G. Knipp, D. Lindley, Stephen M. Carl, Stephanie A. Mowery, W. Roth
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Abstract
Abbreviations: ABC, ATP-binding cassette; A, apical; B, basolateral; BLQ, below the limit of quantitation; EGM, endothelial growth medium; GAPDH, glyceraldehyde-3 phosphate dehydrogenase; GI, gastrointestinal; HBSS, Hank’s balanced salt solution; hPepT, human oligopeptide transporter; hPHT, human peptide/histidine transporter; MES, 2-(N-morpholino)ethanesulfonic acid; MDR, multidrug resistance; MRP, multidrug resistance-like protein; qRT-PCR, quantitative reverse transcriptase-polymerase chain reaction; P-gp, P-glycoprotein; POT, proton-dependent oligopeptide transporter; RP L13a, ribosomal protein L13a; SLC, solute carrier transporter
人多肽/组氨酸转运蛋白1 (hPHT1/SLC15A4)功能的评估:在hCMEC/D3血脑屏障细胞系中利用hPHT1 shRNA稳定转染敲低的转运动力学
缩写:ABC, atp结合盒;一个顶端;B,基底;BLQ，低于定量限度;EGM，内皮生长培养基;GAPDH，甘油醛-3磷酸脱氢酶;胃肠道、肠胃;HBSS，汉克平衡盐溶液;hPepT，人寡肽转运蛋白;hPHT，人肽/组氨酸转运蛋白;MES, 2-(N-morpholino)乙磺酸;MDR，耐多药;MRP，多药耐药样蛋白;定量逆转录聚合酶链反应;P-gp 22;质子依赖性寡肽转运蛋白;RP L13a，核糖体蛋白L13a;溶质载流子输运体
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