From low arterial- to low tissue-oxygenation strategy. An evolutionary theory

J.-C Massabuau
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引用次数: 72

Abstract

The primitive atmosphere where aerobic life started on earth was hypoxic and hypercapnic. Remarkably, an adaptation strategy whereby O2 partial pressure, PO2, in the arterial blood is maintained within a low and narrow range of 1–3 kPa, largely independent of inspired PO2, has also been reported in modern water-breathers. In mammalian tissues, including brain, the most frequently measured PO2 is in the same low range. Based on the postulate that basic cellular machinery has been established since the early stages of evolution, we propose that this similarity in oxygenation status is the consequence of an early adaptation strategy which, subsequently throughout the course of evolution, maintained cellular oxygenation in the same low and primitive range independent of environmental changes. The rational for such an evolutionary theory is discussed in terms of an equilibrium between physiological and pathological reactions associated with O2 excess vs O2 lack and emerging concepts about the importance of cellular O2-dependent mechanisms in the low but physiological PO2 range.

从低动脉氧合到低组织氧合策略。进化理论
地球上有氧生命开始的原始大气是缺氧和高碳酸的。值得注意的是,在现代水呼吸动物中也有一种适应策略,即动脉血中的O2分压(PO2)维持在1-3 kPa的低而狭窄的范围内,在很大程度上与吸入的PO2无关。在包括大脑在内的哺乳动物组织中,最常测量到的PO2也处于同样低的范围内。基于基本的细胞机制在进化的早期阶段就已经建立的假设,我们提出这种氧合状态的相似性是早期适应策略的结果,该策略随后在整个进化过程中将细胞氧合维持在相同的低原始范围内,而不受环境变化的影响。这种进化理论的合理性是根据与O2过量与O2缺乏相关的生理和病理反应之间的平衡以及在低但生理PO2范围内细胞O2依赖机制的重要性的新兴概念进行讨论的。
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