Synthesis and Anti tubercular activity of some new N’-(3-hydroxy-3, 4-dihydroquinoxaline-2-carbonyl)-N-phenylcarbamimidic acid derivatives

Abstract

A new series new N’-(3-hydroxy-3,4-dihydroquinoxaline-2-carbonyl)-N-phenylcarbamimidic acid derivatives were designed and synthesized. The newly synthesized compounds were evaluated for their anti-tb activity. The structure of the synthesized compounds was confirmed by elemental analysis and spectral data (IR, 1H NMR and Mass). The data obtained from biological screening revealed that; synthesized compounds showed the good to moderate anti-tb activities. Keywords: Quinoxaline, Orthophenylenediamine, Alloxane and antimycobacterial.